Can You Take Nyquil and Benadryl?

Lots of people use medicine from the store when they feel sick with a cold, allergies, or the flu. Two common ones are Nyquil and Benadryl, which help with different symptoms. But is it okay to take them both at the same time? Let’s find out.

What is Nyquil?

Nyquil is a well-known over-the-counter medicine used to treat symptoms of the common cold, flu, and allergies. It usually comprises a combination of active substances such as acetaminophen, dextromethorphan, and doxylamine succinate. Each ingredient has a unique purpose, such as lowering temperature, suppressing cough, or causing sleepiness.

Follow the prescribed dosage guidelines on the package or as instructed by a healthcare practitioner. Excess acetaminophen consumption might cause liver damage.

What is Nyquil Used For?

It is commonly used to treat cough, runny nose, sneezing, sore throat, headache, fever, and minor aches and pains. Acetaminophen (a pain reliever/fever reducer), dextromethorphan (a cough suppressant), doxylamine (an antihistamine), and, sometimes, phenylephrine (a decongestant) are common components in NyQuil.

What is Nyquil Used For?

What is Benadryl?

Benadryl, on the other hand, is an antihistamine medicine used to treat allergies, hay fever, and cold symptoms such as sneezing, itching, watery eyes, and runny nose. Benadryl’s key ingredient is diphenhydramine hydrochloride, which blocks the activity of histamine, a chemical in the body that produces allergic reactions.

Uses Of Benadryl

Benadryl is an over-the-counter medicine used to treat allergic reactions such as itching, sneezing, runny nose, watery eyes, hives, and rashes. It contains the active ingredient diphenhydramine, an antihistamine that reduces allergy symptoms by blocking the effects of histamine, a chemical produced by the body during an allergic reaction.

In addition to its antihistamine characteristics, Benadryl can also be used for the following purposes:

  • Sleep Aid: Because of its sedative properties, Benadryl is occasionally used as a sleep aid to help those who experience occasional sleeplessness or difficulties falling asleep.
  • Motion Sickness: Benadryl’s hypnotic and anti-nausea effects can help ease motion sickness symptoms like nausea and vomiting.
  • Allergic Reactions: Benadryl can be used to treat mild allergic reactions like bug bites or stings, as well as to relieve itching and swelling.
  • Cold and Flu: Benadryl may be used to treat common cold or flu symptoms such as sneezing, runny nose, and watery eyes, especially if they are caused by allergies.

Can You Take Nyquil and Benadryl Together?

While both Nyquil and Benadryl are typically safe when taken as prescribed, mixing them is not always suggested. Both drugs can produce tiredness and drowsiness and taking them together could increase their effects, potentially resulting in excessive fatigue, anxiety, and confusion.

Furthermore, mixing Nyquil and Benadryl may raise the chance of other adverse effects such as dry mouth, blurry vision, urine retention, and constipation. Individuals with particular medical conditions, such as respiratory illnesses, liver disease, or urinary retention, may be more susceptible to the side effects of this combination of drugs.

Before combining Nyquil and Benadryl, check with a healthcare expert, especially if you are taking other medications or have underlying health conditions. They may give you specific recommendations based on your medical history and current prescriptions, ensuring your safety and well-being.

Can You Take Nyquil and Benadryl Together?

Common Side Effects Of Combining Nyquil and Benadryl

If you take NyQuil and Benadryl together, it might make you feel more sleepy or dizzy than usual. That’s because they both have something called diphenhydramine in them, which can make you feel drowsy. So, if you take them together, it can make you feel even more tired and dizzy than if you just took one of them.

Some common side effects of combining NyQuil and Benadryl may include:

  1. Excessive drowsiness: Taking NyQuil and Benadryl combined might amplify diphenhydramine’s sedative effects, resulting in excessive sleepiness and weariness.
  2. Dizziness: Combining these drugs may cause dizziness or lightheadedness, making it difficult to focus or perform tasks that need attentiveness.
  3. Impaired coordination: The combination of NyQuil and Benadryl may impair motor skills and coordination, increasing the risk of accidents or falls.
  4. Blurred vision: Some people may experience impaired vision or difficulties focusing while taking both drugs at the same time.
  5. Dry mouth and throat: Both NyQuil and Benadryl can produce dry mouth and throat as side effects, which may worsen when used simultaneously.
  6. Constipation: Diphenhydramine can have anticholinergic properties, which may cause constipation when coupled with other drugs such as those found in NyQuil.

Can You Take Nyquil with Amoxicillin?

Yes, you can take NyQuil with amoxicillin, but you should see your doctor or pharmacist first to confirm safety and avoid any problems. NyQuil is a combination drug intended to treat the symptoms of the common cold, flu, allergies, and other respiratory ailments, whereas amoxicillin is an antibiotic used to treat bacterial infections.

TotalStable indicates no direct interaction between NyQuil and amoxicillin. It is important to exercise caution because NyQuil contains several active ingredients, including acetaminophen, dextromethorphan, doxylamine, and phenylephrine. Some of these components may cause interactions with other drugs or medical conditions.

More: How To Sleep After Gallbladder Surgery (2024)


Nyquil and Benadryl can help when you have a cold or allergies. But if you take them together, it might not be safe. They could make you extra sleepy or cause other problems. It’s really important to talk to a doctor before using both at the same time.

Just make sure to follow the right amount of medicine to stay safe. And if you can, think about other ways to feel better without taking both. That way, you can treat your symptoms without worrying too much about getting sick.

Frequently Asked Questions

Can I Take Nyquil and Benadryl Together?

Yes, you can take Nyquil and Benadryl together, but be cautious. Both of these drugs have comparable chemicals that might cause sleepiness. Taking them together may enhance sleepiness, so ask your doctor before doing so.

Is It Safe to Mix Nyquil and Benadryl?

Mixing Nyquil with Benadryl can be safe for some people, but it’s important to understand the hazards. Both drugs contain chemicals that may induce drowsiness and dizziness. It is best to consult with a healthcare expert before combining them, especially if you have any underlying health concerns or are taking other medications.

What Happens If You Take Nyquil and Benadryl Together?

If you take Nyquil and Benadryl combined, you may suffer more tiredness, dizziness, and problems concentrating. In other situations, it might cause more serious side effects such as disorientation, blurred vision, and difficulty breathing.

Can I Take Nyquil and Benadryl at Different Times?

Yes, you can take Nyquil and Benadryl at different times if necessary. Because both medications might cause sleepiness, it may be best to take them at different times of the day to avoid feeling too drowsy.

What Should I Do If I Accidentally Took Nyquil and Benadryl Together?

Unintentionally combined Nyquil and Benadryl, monitor for symptoms like drowsiness, confusion, or breathing difficulties. Seek medical attention if serious. Be cautious when reading labels.

Related Articles


  1. My brother suggested I might like this website He was totally right This post actually made my day You cannt imagine just how much time I had spent for this information Thanks

  2. I was recommended this website by my cousin I am not sure whether this post is written by him as nobody else know such detailed about my trouble You are amazing Thanks

Leave a Reply

Your email address will not be published. Required fields are marked *

Back to top button